Leicester have beaten Manchester United, Spartak Moscow and Brentford over the last 10 days.
A place in the quarter-finals is at stake at the King Power Stadium on Wednesday night, and Rodgers remains confident he can pick a side capable of overcoming the in-form Seagulls.
“Will there be fresh faces? No doubt,” said the Northern Irishman.
“We can’t use the same players all the time, so we’ll definitely make changes, but it doesn’t take away the fact we want to win the game. We’ll be bringing good players into the game.
“We’ll recover, do some preparation work, and then look to get to the quarter-finals.”
Jamie Vardy is one of the players set to be rested having come off at half-time at Brentford with a knee problem.
The former England striker was replaced by Patson Daka, the four-goal hero of Moscow who is pushing for another start.
“He felt something in the warm-up. When he came in he felt something in his knee but he felt OK to give it a go,” added Rodgers.
“I could just see he wasn’t quite moving the same. He wasn’t quite as dynamic and didn’t have that speed that he normally has, so there was no point risking it any further.
“We made the change and brought in Patson, who was fresh and confident after his midweek performance.”