All you need to know before the Premier League fixture
Ole Gunnar Solskjaer’s side have three wins and a draw in the league so far and saw Cristiano Ronaldo mark his return to the club with a double against Newcastle last weekend.
West Ham will be missing their own free-scorer – Michail Antonio is suspended.
The Europa League competitors are also unbeaten but have drawn their last two games against Crystal Palace and Southampton.
Here’s all the information you need before the fixture.
When is it?
The match will kick off at 2pm on Sunday 19 September at the London Stadium.
How can I watch?
It will be shown live on Sky Sports Main Event and Premier League, with coverage starting from 1pm. If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
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West Ham will be forced to alter their approach after Michail Antonio’s suspension, short as David Moyes is of an alternative striking option. Jarrod Bowen may be shifted inside and Moyes may opt to return to a back-five with which he has previously had success at the club, particularly with a glut of centre-back options.
Conversely, Manchester United will have Aaron Wan-Bissaka available – he is only suspended in Europe. Edinson Cavani is a doubt after not travelling to Switzerland while Marcus Rashford remains out.
West Ham: Fabianski; Coufal, Zouma, Dawson, Ogbonna, Cresswell; Rice, Soucek; Benrahma, Bowen, Fornals
Manchester United: De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Pogba, Matic; Greenwood, Fernandes, Sancho; Ronaldo
West Ham: 10/3
Manchester United: 3/4
West Ham will hope to challenge Manchester United but shorn of Michail Antonio, they may be lacking both forward thrust and a useful out-ball. They have the defensive resources to frustrate but stopping a fully-loaded Manchester United side may prove difficult. West Ham 1-2 Manchester United