The Miami-Dade Fire Rescue service tweeted that they are on the scene at the apartment block, believed to be named Champlain Towers South, near 88 Street & Collins Avenue.
More than 80 rescue units have responded to the incident, including Technical Rescue Teams and municipal fire departments.
Multiple casualties are feared but none are as yet confirmed. It is unclear what caused the collapse and whether anybody remains trapped in the rubble.
Breaking updates as they come.
Traffic diverted away from scene
Vehicles are being kept clear of the collapse, the fire department say.
Watch: Rubble surrounds partially collapsed building
Footage taken at the scene shows the extent of the rubble generated by the collapse.
Watch: Social media users share footage of rubble
Miami locals are sharing photos and videos of the collapse to social media.
Jamal Akakpo says he was staying in a hotel next to the building and was asked to evacuate to a nearby recreational centre.
His footage shows emergency crews surrounding the rubble.
Media staging area set up
Reporters have been positioned in a field near the scene, the Miami-Dade Fire Rescue service say.
More than 80 fire units are on the scene
The Miami-Dade Fire Rescue service is on the scene of the “partial building collapse” near 88 Street & Collins Avenue.