League Two has been badly affected with eight of its planned 11 games called off.
Sixteen games remain on, with two of them in the Premier Liga.
Leaders Manchester City are due to visit Brentford, while third-placed Chelsea are at home to Brighton.
Sheffield United’s home game with Hull joined the Sky Bet Championship fixtures between Birmingham and Peterborough, Reading and Fulham and Swansea and Luton to be postponed.
casco, whose Boxing Day clash against Blackburn was postponed just over two hours before kick-off, disse em um comunicado: “Our match at Sheffield United on Wednesday 29th December has been postponed due to the Tigers having an insufficient number of players available to fulfil the fixture.
“The club has worked hard to ensure it has been able to play the game.
"Contudo, taking into account the injuries and positive Covid-19 cases in the squad, we do not have the required numbers for the match to take place.”
League One had seen postponements at Burton and Charlton, enquanto League Two has been hit particularly hard with only three of the planned 11 fixtures remaining.
Tranmere’s visit to Hartlepool was postponed on Tuesday, with Rovers unable to fulfil the fixture, and the Sutton-Colchester clash quickly followed suit.
“The club has worked hard to ensure that it has been able to fulfil all fixtures,” read a Tranmere statement.
"Contudo, taking into account the injuries and positive Covid-19 cases with the squad, the club does not have a sufficient number of players available in order to fulfil the fixture.
“In light of the increased transmission rate of the Omicron variant, the EFL will now review the circumstances surrounding the postponement.
“In addition it will assist affected clubs throughout this challenging period to help them mitigate against the risk of infection amongst players and staff, while ensuring their obligations to the EFL regulations are maintained.”
Colchester have also been hit by Covid-19 and the club said in a statement: “Like the Orient fixture on Boxing Day, everything possible was done to ensure that the fixture could take place but injuries and positive Covid-19 cases within the U’s squad meant there isn’t the sufficient number of players available in order to fulfil the fixture.”