Alles wat u moet weet
United are chasing another three points after sinking Villarreal with a last-minute winner thanks to Cristiano Ronaldo
Atalanta meanwhile are top with four points, and will prove stiff opposition.
Here is everything you need to know.
Wanneer is die wedstryd?
Manchester United vs Atalanta is tonight, Woensdag 19 Oktober, at 8pm BST.
Hoe kan ek daarna kyk?
The game will be shown live in the UK on BT Sport. Subscribers can stream online via the BT Sport app and BT Sport website.
Wat is die spannuus?
Manchester United will be without the injured Raphael Varane and Anthony Martial, while Aaron Wan-Bissaka returns from suspension. Atalanta are without injured wingbacks Hans Hateboer and Robin Gosens.
Manchester United: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Pogba, Fernandes, Greenwood; Ronaldo.
Atalanta: Musso; Palomino, Demiral, Toloi; Zappacosta, Freuler, De Roon, Pragtige; Malinovskyi, Ilicic, Zapata.
Man United 3/4
United desperately need a victory to lift morale after a hammering at Leicester on the weekend, and have the firepower to get one here. Manchester United 2-0 Atalanta.